Direct metabolic precursor to serotonin, derived from Griffonia simplicifolia seeds, bypassing the rate-limiting step in serotonin synthesis; must not be combined with SSRIs, MAOIs, or other serotonergic drugs due to serotonin syndrome risk.
Support for reducing substance dependence, managing cravings, and restoring neurotransmitter balance during recovery.
Also known as: 5-Hydroxytryptophan, Griffonia simplicifolia
Every published result for this pair, extracted and audited.
Research volume over time for 5-HTP × addiction recovery. Structured outcome extraction (direction, effect size) for this pair is in progress - the full analytics will appear here once audited.
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysisJavelle F, et al. · Nutrition reviews · 2020PMID 31504850 ↗02Symptomatic treatment of interferon-α-induced depression in hepatitis C: a systematic reviewBaraldi S, et al. · Journal of clinical psychopharmacology · 2012PMID 22722514 ↗03Tryptophan and 5-hydroxytryptophan for depressionShaw K, et al. · The Cochrane database of systematic reviews · 2002PMID 11869656 ↗04Are tryptophan and 5-hydroxytryptophan effective treatments for depression? A meta-analysisShaw K, et al. · The Australian and New Zealand journal of psychiatry · 2002PMID 12169147 ↗05Tryptophan and 5-hydroxytryptophan for depressionShaw K, et al. · The Cochrane database of systematic reviews · 2001Be the first to share what you noticed with 5-HTP for addiction recovery. How we calculate this.