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Delta-9-tetrahydrocannabinol, the primary psychoactive cannabinoid in Cannabis sativa, acting as a partial agonist at CB1 receptors; used medically for chronic pain, chemotherapy-induced nausea, appetite stimulation, and spasticity. Subject to legal restrictions varying by jurisdiction.
Generalized anxiety, social anxiety, panic disorder, and related conditions. Affects 1 in 6 people in the UK.
Also known as: THC, Delta-9-tetrahydrocannabinol, Marijuana, Cannabis sativa
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Cannabis (THC) in anxiety.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 30758486 2019 | Meta-analysis | 23 317 | - | Anxiety | reported qualitatively (95% CI, 0.84-1.67; I2=42%) | No benefit |
| PMID 30758486 2019 | Meta-analysis | 23 317 | - | Depression | 1.37 OR (95% CI, 1.16-1.62; I2=0%) | Harm / risk |
| PMID 30758486 2019 | Meta-analysis | 23 317 | - | Suicidal attempt | 3.46 OR (95% CI, 1.53-7.84, I2=61.3%) | Harm / risk |
| PMID 30758486 2019 | Meta-analysis | 23 317 | - | Suicidal ideation | 1.50 OR (95% CI, 1.11-2.03; I2=0%) | Harm / risk |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Cannabis-Based Products for Chronic Pain : An Updated Systematic ReviewChou R, et al. · Annals of internal medicine · 2026PMID 41429020 ↗02The effects of oral cannabidiol supplementation on blood pressure in adults: a systematic review of randomised controlled trialsRoberts A, et al. · Journal of cannabis research · 2026PMID 42321899 ↗03Transdiagnostic reduction in cortical choline-containing compounds in anxiety disorders: a (1)H-magnetic resonance spectroscopy meta-analysisMaddock RJ, et al. · Molecular psychiatry · 2025PMID 40913113 ↗04Effects of Different Cannabinoid Formulations on Anxiety-Related Disorders, and Tourette Syndrome: A Systematic Review and Meta-AnalysisRaminelli AO, et al. · Cannabis and cannabinoid research · 2025PMID 40956670 ↗Be the first to share what you noticed with Cannabis (THC) for anxiety. How we calculate this.