Compound library
Understand what people are taking.
Browse medicines, supplements, herbs, and health foods. Each profile brings community reports and linked research into one clear view.
Browse medicines, supplements, herbs, and health foods. Each profile brings community reports and linked research into one clear view.
The simplest amino acid: an inhibitory brain messenger and a building block of collagen and glutathione. Human evidence is thin. Small trials report better sleep and less next-day tiredness with 3 g at bedtime, and one 74-person trial lowered HbA1c in type 2 diabetes, but a 2024 systematic review rates the sleep studies as small with a high risk of bias. 'GlyNAC' trials combine it with NAC, so they cannot show what glycine does alone.
7 of 8 results reported a benefit, from 3 published studies.
3 randomised trials, 12 people
These are the figures the studies reported, not a prediction for any one person. Where several studies measured the same thing in the same unit, we show a simple average and say so. Every individual result is listed below.
See every resultInsulin resistance, pre-diabetes, type 2 diabetes, and metabolic syndrome.
Also known as: Glycine supplement
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Glycine in blood sugar control.
Study designs behind these findings.
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Adjunctive berberine for schizophrenia with metabolic syndrome: a systematic review and meta-analysisXie K, et al. · Frontiers in psychiatry · 2026PMID 42433212 ↗02The Effect of Berberine Supplementation on Glycemic Control and Inflammatory Biomarkers in Metabolic Disorders: An Umbrella Meta-analysis of Randomized Controlled TrialsNazari A, et al. · Clinical therapeutics · 2024PMID 38016844 ↗03Effect of Fenugreek on Hyperglycemia: A Systematic Review and Meta-AnalysisShabil M, et al. · Medicina (Kaunas, Lithuania) · 2023PMID 36837450 ↗04Effect of saffron and fenugreek on lowering blood glucose: A systematic review with meta-analysisCorreia AGDS, et al. · Phytotherapy research : PTR · 2023PMID 36992660 ↗Be the first to share what you noticed with Glycine for blood sugar control. Why counts start empty.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 18852529 2008 | Randomised trial | Seventy-four | 3 months | A1C levels | reported qualitatively | Benefit |
| PMID 18852529 2008 | Randomised trial | Seventy-four | 3 months | Interferon-gamma level (rose with glycine, fell with placebo) | reported qualitatively | Benefit |
| PMID 18852529 2008 | Randomised trial | Seventy-four | 3 months | TNF-receptor I levels | reported qualitatively | Benefit |
| PMID 12450897 2002 | Randomised trial | Nine | 2-h | Plasma glucose area response | > 50% | Benefit |
| PMID 11456285 2001 | Randomised trial | 12 | - | early insulin response | reported qualitatively (p < 0.05) | Benefit |
| PMID 11456285 2001 | Randomised trial | 12 | - | insulin action | reported qualitatively | No benefit |
| PMID 11456285 2001 | Randomised trial | 12 | - | late insulin response | reported qualitatively (p < 0.05) | Benefit |
| PMID 11456285 2001 | Randomised trial | 12 | - | total insulin response | reported qualitatively (p < 0.02) | Benefit |