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Amino acid from tea leaves that crosses the blood-brain barrier and increases alpha-wave brain activity; promotes calm alertness without sedation, often paired with caffeine.
Generalized anxiety, social anxiety, panic disorder, and related conditions. Affects 1 in 6 people in the UK.
Also known as: Theanine, L-gamma-glutamylethylamide
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for L-Theanine in anxiety.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 31758301 2020 | Systematic review | - | - | reduction of stress and anxiety | reported qualitatively | Benefit |
| PMID 28899506 2017 | Systematic review | - | - | brain function (e.g. activation of working memory) | reported qualitatively | Benefit |
| PMID 28899506 2017 | Systematic review | - | - | cognition (e.g. benefits in memory and attention) | reported qualitatively | Benefit |
| PMID 28899506 2017 | Systematic review | - | - | psychopathological symptoms (e.g. reduction of anxiety) | reported qualitatively | Benefit |
| PMID 31623400 2019 | Randomised trial | 30 | four weeks | Executive function | reported qualitatively (p = 0.031) | Benefit |
| PMID 31623400 2019 | Randomised trial | 30 | four weeks | Letter fluency (lower half subgroup) | reported qualitatively (p = 0.002) | Benefit |
| PMID 31623400 2019 | Randomised trial | 30 | four weeks | Pittsburgh Sleep Quality Index | reported qualitatively (p = 0.013) | Benefit |
| PMID 31623400 2019 | Randomised trial | 30 | four weeks | PSQI subscale: sleep latency, sleep disturbance, use of sleep medication | reported qualitatively (all p < 0.05) | Benefit |
| PMID 31623400 2019 | Randomised trial | 30 | four weeks | Self-rating Depression Scale | reported qualitatively (p = 0.019) | Benefit |
| PMID 31623400 2019 | Randomised trial | 30 | four weeks | State-Trait Anxiety Inventory-trait | reported qualitatively (p = 0.006) | Benefit |
| PMID 31623400 2019 | Randomised trial | 30 | four weeks | Verbal fluency | reported qualitatively (p = 0.001) | Benefit |
| PMID 31623400 2019 | Randomised trial | 30 | four weeks | Verbal fluency (lower half subgroup) | reported qualitatively (p = 0.002) | Benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Transdiagnostic reduction in cortical choline-containing compounds in anxiety disorders: a (1)H-magnetic resonance spectroscopy meta-analysisMaddock RJ, et al. · Molecular psychiatry · 2025PMID 40913113 ↗02Effects of Different Cannabinoid Formulations on Anxiety-Related Disorders, and Tourette Syndrome: A Systematic Review and Meta-AnalysisRaminelli AO, et al. · Cannabis and cannabinoid research · 2025PMID 40956670 ↗03Effectiveness of Cannabidiol to Manage Chronic Pain: A Systematic ReviewMohammed SYM, et al. · Pain management nursing : official journal of the American Society of Pain Management Nurses · 2024PMID 37953193 ↗04Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancyMinozzi S, et al. · The Cochrane database of systematic reviews · 2024PMID 38682758 ↗Be the first to share what you noticed with L-Theanine for anxiety. How we calculate this.