Spice from the stigmas of Crocus sativus; its crocin and safranal compounds inhibit serotonin, dopamine, and noradrenaline reuptake, with small trials showing effects on mild-to-moderate depression comparable to low-dose SSRIs.
Depression that follows a seasonal pattern, typically worsening in winter months with reduced sunlight.
Also known as: Crocus sativus
Every published result for this pair, extracted and audited.
Research volume over time for Saffron × seasonal affective disorder (sad). Structured outcome extraction (direction, effect size) for this pair is in progress - the full analytics will appear here once audited.
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Effect of Saffron Versus Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment of Depression and Anxiety: A Meta-analysis of Randomized Controlled TrialsShafiee A, et al. · Nutrition reviews · 2025PMID 38913392 ↗02Comparative efficacy and tolerability of nutraceuticals for depressive disorder: A systematic review and network meta-analysisCheng YC, et al. · Psychological medicine · 2025PMID 40314175 ↗03New horizons for the study of saffron (Crocus sativus L.) and its active ingredients in the management of neurological and psychiatric disorders: A systematic review of clinical evidence and mechanismsHan S, et al. · Phytotherapy research : PTR · 2024PMID 38424688 ↗04Be the first to share what you noticed with Saffron for seasonal affective disorder (sad). How we calculate this.