Compound library
Understand what people are taking.
Browse medicines, supplements, herbs, and health foods. Each profile brings community reports and linked research into one clear view.
Browse medicines, supplements, herbs, and health foods. Each profile brings community reports and linked research into one clear view.
Polyamine found in wheat germ, soybeans and aged cheese, promoted as an autophagy ('cell clean-up') booster because it extends lifespan in animals. In humans even the biochemical step is unconfirmed: placebo-controlled trials at 15 mg and 40 mg a day did not raise blood spermidine, and the largest trial (SmartAge, 12 months, 100 older adults) found no memory benefit.
3 of 3 results reported a benefit, from 1 published study.
1 randomised trial, 40 people
These are the figures the studies reported, not a prediction for any one person. Where several studies measured the same thing in the same unit, we show a simple average and say so. Every individual result is listed below.
See every resultFrequent illness, weak immune response, slow recovery from infections.
Also known as: Spermidine (wheat germ extract)
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Spermidine in immune support.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 42169618 2026 | Randomised trial | 40 | 13 weeks | Memory B cell recall responses in vaccine non-responders | reported qualitatively | Benefit |
| PMID 42169618 2026 | Randomised trial | 40 | 13 weeks | Neutralising antibody activity in vaccine non-responders | reported qualitatively | Benefit |
| PMID 42169618 2026 | Randomised trial | 40 | 13 weeks | Spike-specific IgG secretion in vaccine non-responders | reported qualitatively | Benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Comparison of adjuvant and neoadjuvant therapies for muscle invasive bladder cancer: A network meta-analysisPetrelli F, et al. · Urologic oncology · 2026PMID 40935764 ↗02Clinical benefits and risks of high-dose intravenous vitamin C: a systematic reviewAlangari A, et al. · Journal of medicine and life · 2026PMID 41815850 ↗03Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026Weiss SL, et al. · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026PMID 41869844 ↗04Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026Weiss SL, et al. · Intensive care medicine · 2026PMID 41870559 ↗Be the first to share what you noticed with Spermidine for immune support. Why counts start empty.