| Blood pressure (BP) | Chlorella did not significantly improve Blood pressure (BP) with no comparator reported in 168 to 279.No clear benefit | no number reported | 168 to 279 | — | Meta-analysis · 2025 | PMID 40289965 |
| Diastolic blood pressure | Spirulina improved Diastolic blood pressure (-0.42; 95% CI: -0.81 to -0.02; p = 0.04) with no comparator reported in 101 to 299. (95% CI: -0.81 to -0.02; p = 0.04)Benefit seen | -0.42 | 101 to 299 | — | Meta-analysis · 2025 | PMID 40289965 |
| Lipemia | Chlorella did not significantly improve Lipemia with no comparator reported in 168 to 279.No clear benefit | no number reported | 168 to 279 | — | Meta-analysis · 2025 | PMID 40289965 |
| Lipemia indexes | Spirulina did not significantly improve Lipemia indexes with no comparator reported in 101 to 299.No clear benefit | no number reported | 101 to 299 | — | Meta-analysis · 2025 | PMID 40289965 |
| Total cholesterol | Spirulina did not significantly improve Total cholesterol (-0.17; 95% CI: -0.39 to 0.06; p = 0.15) with no comparator reported in 101 to 299. (95% CI: -0.39 to 0.06; p = 0.15)No clear benefit | -0.17 | 101 to 299 | — | Meta-analysis · 2025 | PMID 40289965 |
| BMI | Spirulina improved BMI (-0.58 kg/m²; P = 0.001) compared with placebo in 35 trials. (P = 0.001)Benefit seen | -0.58 kg/m² | 35 trials | — | Meta-analysis · 2025 | PMID 40953712 |
| DBP | Spirulina improved DBP (-3.09 mmHg; P < 0.001) compared with placebo in 35 trials. (P < 0.001)Benefit seen | -3.09 mmHg | 35 trials | — | Meta-analysis · 2025 | PMID 40953712 |
| FBG | Spirulina improved FBG (-5.51 (mg/dl); P = 0.001) compared with placebo in 35 trials. (P = 0.001)Benefit seen | -5.51 (mg/dl) | 35 trials | — | Meta-analysis · 2025 | PMID 40953712 |
| HDL-C | Spirulina improved HDL-C (1.9 (mg/dl); P < 0.001) compared with placebo in 35 trials. (P < 0.001)Benefit seen | 1.9 (mg/dl) | 35 trials | — | Meta-analysis · 2025 | PMID 40953712 |
| HOMA-IR | Spirulina improved HOMA-IR (-0.68; P < 0.001) compared with placebo in 35 trials. (P < 0.001)Benefit seen | -0.68 | 35 trials | — | Meta-analysis · 2025 | PMID 40953712 |
| hs-CRP | Spirulina improved hs-CRP (-0.86 mg/L; P = 0.002) compared with placebo in 35 trials. (P = 0.002)Benefit seen | -0.86 mg/L | 35 trials | — | Meta-analysis · 2025 | PMID 40953712 |
| IL-6 | Spirulina improved IL-6 (-0.58 pg/ml; P < 0.001) compared with placebo in 35 trials. (P < 0.001)Benefit seen | -0.58 pg/ml | 35 trials | — | Meta-analysis · 2025 | PMID 40953712 |
| insulin | Spirulina improved insulin (-0.86 (ng/ml); P = 0.002) compared with placebo in 35 trials. (P = 0.002)Benefit seen | -0.86 (ng/ml) | 35 trials | — | Meta-analysis · 2025 | PMID 40953712 |
| LDL-C | Spirulina improved LDL-C (-7.69 (mg/dl); P < 0.001) compared with placebo in 35 trials. (P < 0.001)Benefit seen | -7.69 (mg/dl) | 35 trials | — | Meta-analysis · 2025 | PMID 40953712 |
| SBP | Spirulina improved SBP (-3.85 mmHg; P = 0.002) compared with placebo in 35 trials. (P = 0.002)Benefit seen | -3.85 mmHg | 35 trials | — | Meta-analysis · 2025 | PMID 40953712 |
| TC | Spirulina improved TC (-11.5 (mg/dl); P < 0.001) compared with placebo in 35 trials. (P < 0.001)Benefit seen | -11.5 (mg/dl) | 35 trials | — | Meta-analysis · 2025 | PMID 40953712 |
| TG | Spirulina improved TG (-14.75 (mg/dl); P < 0.001) compared with placebo in 35 trials. (P < 0.001)Benefit seen | -14.75 (mg/dl) | 35 trials | — | Meta-analysis · 2025 | PMID 40953712 |
| TNF-α | Spirulina improved TNF-α (-0.46 pg/ml; P = 0.01) compared with placebo in 35 trials. (P = 0.01)Benefit seen | -0.46 pg/ml | 35 trials | — | Meta-analysis · 2025 | PMID 40953712 |
| weight | Spirulina improved weight (-1.78 kg; P = 0.003) compared with placebo in 35 trials. (P = 0.003)Benefit seen | -1.78 kg | 35 trials | — | Meta-analysis · 2025 | PMID 40953712 |
| fasting blood sugar (FBS) | Arthrospira (Spirulina) improved fasting blood sugar (FBS) ((0.63- 2.90-) 1.77-) with no comparator reported.Benefit seen | (0.63- 2.90-) 1.77- | — | — | Meta-analysis · 2022 | PMID 34538515 |
| glycated hemoglobin A1c (HbA1C) | Arthrospira (Spirulina) did not significantly improve glycated hemoglobin A1c (HbA1C) ((1.04 ، 2.23-) 0.59-) with no comparator reported; the difference versus the comparator was not statistically established.No clear benefit | (1.04 ، 2.23-) 0.59- | — | — | Meta-analysis · 2022 | PMID 34538515 |
| high-density lipoprotein cholesterol (HDL-C) | Arthrospira (Spirulina) improved high-density lipoprotein cholesterol (HDL-C) ((3.86 ، 0.67) 2.27) with no comparator reported.Benefit seen | (3.86 ، 0.67) 2.27 | — | — | Meta-analysis · 2022 | PMID 34538515 |
| low-density lipoprotein cholesterol (LDL-C) | Arthrospira (Spirulina) did not significantly improve low-density lipoprotein cholesterol (LDL-C) with no comparator reported; the difference versus the comparator was not statistically established.No clear benefit | no number reported | — | — | Meta-analysis · 2022 | PMID 34538515 |
| total cholesterol (TC) | Arthrospira (Spirulina) improved total cholesterol (TC) ((0.46- ، 4.61-) 2.54-) with no comparator reported.Benefit seen | (0.46- ، 4.61-) 2.54- | — | — | Meta-analysis · 2022 | PMID 34538515 |
| triglycerides (TG) | Arthrospira (Spirulina) improved triglycerides (TG) ((0.89- ، 6.54-) 3.71-) with no comparator reported.Benefit seen | (0.89- ، 6.54-) 3.71- | — | — | Meta-analysis · 2022 | PMID 34538515 |
| fasting plasma glucose (FPG) | Spirulina improved fasting plasma glucose (FPG) (-10.31; 95% confidence interval, CI [-16.21, -4.42]) with no comparator reported. (95% confidence interval, CI [-16.21, -4.42])Benefit seen | -10.31 | — | — | Meta-analysis · 2019 | PMID 31359513 |
| high-density lipoprotein cholesterol (HDL-C) | Spirulina improved high-density lipoprotein cholesterol (HDL-C) (1.42; 95% CI [0.16, 2.68]) with no comparator reported. (95% CI [0.16, 2.68])Benefit seen | 1.42 | — | — | Meta-analysis · 2019 | PMID 31359513 |
| insulin concentrations | Spirulina improved insulin concentrations (-0.53; 95% CI [-0.62, -0.44]) with no comparator reported. (95% CI [-0.62, -0.44])Benefit seen | -0.53 | — | — | Meta-analysis · 2019 | PMID 31359513 |
| low-density lipoprotein cholesterol (LDL-C) | Spirulina improved low-density lipoprotein cholesterol (LDL-C) (-19.02; 95% CI [-36.27, -1.78]) with no comparator reported. (95% CI [-36.27, -1.78])Benefit seen | -19.02 | — | — | Meta-analysis · 2019 | PMID 31359513 |
| total cholesterol | Spirulina improved total cholesterol (-20.50; 95% CI [-38.25, -2.74]) with no comparator reported. (95% CI [-38.25, -2.74])Benefit seen | -20.50 | — | — | Meta-analysis · 2019 | PMID 31359513 |
| very low-density lipoprotein cholesterol (VLDL-C) | Spirulina improved very low-density lipoprotein cholesterol (VLDL-C) (-6.72; 95% CI [-9.19, -4.26]) with no comparator reported. (95% CI [-9.19, -4.26])Benefit seen | -6.72 | — | — | Meta-analysis · 2019 | PMID 31359513 |
| FBS | Spirulina platensis (S. platensis) improved FBS (↓ 24.94 mg/dL; p < 001) compared with placebo in Sixty (three months). (p < 001)Benefit seen | ↓ 24.94 mg/dL | Sixty | three months | RCT · 2023 | PMID 36598187 |
| HbA1c | Spirulina platensis (S. platensis) improved HbA1c (↓1.43; p < 0.001) compared with placebo in Sixty (three months). (p < 0.001)Benefit seen | ↓1.43 | Sixty | three months | RCT · 2023 | PMID 36598187 |
| HDL-C | Spirulina platensis (S. platensis) improved HDL-C (↑3 mg/dL; p < 0.001) compared with placebo in Sixty (three months). (p < 0.001)Benefit seen | ↑3 mg/dL | Sixty | three months | RCT · 2023 | PMID 36598187 |
| LDL-C | Spirulina platensis (S. platensis) improved LDL-C (↓38.4 mg/dL; p < 0.001) compared with placebo in Sixty (three months). (p < 0.001)Benefit seen | ↓38.4 mg/dL | Sixty | three months | RCT · 2023 | PMID 36598187 |
| TG | Spirulina platensis (S. platensis) improved TG (p < 0.001) compared with placebo in Sixty (three months). (p < 0.001)Benefit seen | no number reported | Sixty | three months | RCT · 2023 | PMID 36598187 |
| Total cholesterol (TC) | Spirulina platensis (S. platensis) improved Total cholesterol (TC) (↓41.36 mg/dL; p < 0.001) compared with placebo in Sixty (three months). (p < 0.001)Benefit seen | ↓41.36 mg/dL | Sixty | three months | RCT · 2023 | PMID 36598187 |