Loading…
Fat-soluble vitamin synthesised in skin from UVB exposure and activated by the liver and kidneys; regulates calcium and phosphate absorption for bone health and modulates immune and mood pathways via vitamin D receptors.
Bone density, osteoporosis prevention, fracture recovery.
Also known as: Cholecalciferol
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Vitamin D3 in bone health.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 35939577 2022 | Randomised trial | 25,871 | median follow-up of 5.3 years | hip fractures | reported qualitatively (hazard ratio, 1.01; 95% CI, 0.70 to 1.47; P=0.96) | No benefit |
| PMID 35939577 2022 | Randomised trial | 25,871 | median follow-up of 5.3 years | nonvertebral fractures | reported qualitatively (hazard ratio, 0.97; 95% CI, 0.87 to 1.07; P=0.50) | No benefit |
| PMID 35939577 2022 | Randomised trial | 25,871 | median follow-up of 5.3 years | total fractures | reported qualitatively (hazard ratio, 0.98; 95% confidence interval [CI], 0.89 to 1.08; P=0.70) | No benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Vitamin D's Impact on Cancer Incidence and Mortality: A Systematic ReviewWimalawansa SJ · Nutrients · 2025PMID 40732958 ↗02Role of vitamin D as adjuvant therapy on multiple sclerosis: an updated systematic review and meta-analysis of randomized controlled trialsSerag I, et al. · European journal of medical research · 2025PMID 40797337 ↗03Population-based interventions for preventing falls and fall-related injuries in older peopleLewis SR, et al. · The Cochrane database of systematic reviews · 2024PMID 38180112 ↗04The effect of vitamin D supplementation on depression: a systematic review and dose-response meta-analysis of randomized controlled trialsGhaemi S, et al. · Psychological medicine · 2024PMID 39552387 ↗Be the first to share what you noticed with Vitamin D3 for bone health. How we calculate this.