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Essential trace mineral and cofactor for over 300 enzymes; supports immune cell function, wound healing, and testosterone synthesis, with topical and oral forms used for acne.
Low testosterone symptoms — low libido, fatigue, muscle loss, mood changes.
Also known as: Zinc Picolinate, Zinc Gluconate, Zinc Citrate
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Zinc in testosterone support.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 20498250 2010 | Systematic review | - | - | Erectile function with PDE5 inhibitors | 1.81 mean difference (95% CI 1.51 to 2.10) | Benefit |
| PMID 20498250 2010 | Systematic review | - | - | Testosterone with zinc in dialysate | 0.19 standardized mean difference (95% CI -2.12 to 2.50) | No benefit |
| PMID 21154382 2010 | Meta-analysis | - | - | Erectile function with PDE5 inhibitors | 10.65 mean difference (95% CI 5.34 to 15.96) | Benefit |
| PMID 21154382 2010 | Meta-analysis | - | - | Testosterone with oral zinc | 1.62 standardised mean difference (95% CI 0.58 to 2.66) | Benefit |
| PMID 21154382 2010 | Meta-analysis | - | - | Testosterone with zinc in dialysate | 0.21 ng/mL (95% CI -2.14 to 2.55) | No benefit |
| PMID 16533356 2006 | Randomised trial | - | 26-week | Endocrine parameters | reported qualitatively | No benefit |
| PMID 16533356 2006 | Randomised trial | 40 | 26-week | Sperm concentration in subfertile men | reported qualitatively | Benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Tissue-specific oxidative stress and protective interventions in malathion-induced toxicity in rodent models: A comprehensive reviewHan D, et al. · Ecotoxicology and environmental safety · 2026PMID 41518979 ↗02Dietary patterns, metabolic pathways and metainflammation in hidradenitis suppurativa: a systematic reviewCelik E, et al. · Frontiers in immunology · 2026PMID 42233037 ↗03Effect of nutritional interventions on the psychological symptoms of premenstrual syndrome in women of reproductive age: a systematic review of randomized controlled trialsRobinson J, et al. · Nutrition reviews · 2025PMID 38684926 ↗04Do "testosterone boosters" really increase serum total testosterone? A systematic reviewMorgado A, et al. · International journal of impotence research · 2024PMID 37697053 ↗Be the first to share what you noticed with Zinc for testosterone support. How we calculate this.