Direct metabolic precursor to serotonin, derived from Griffonia simplicifolia seeds, bypassing the rate-limiting step in serotonin synthesis; must not be combined with SSRIs, MAOIs, or other serotonergic drugs due to serotonin syndrome risk.
Cravings, overeating, and appetite regulation.
Also known as: 5-Hydroxytryptophan, Griffonia simplicifolia
Every published result for this pair, extracted and audited.
Research volume over time for 5-HTP × appetite control. Structured outcome extraction (direction, effect size) for this pair is in progress - the full analytics will appear here once audited.
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysisJavelle F, et al. · Nutrition reviews · 2020PMID 31504850 ↗02Symptomatic treatment of interferon-α-induced depression in hepatitis C: a systematic reviewBaraldi S, et al. · Journal of clinical psychopharmacology · 2012PMID 22722514 ↗03Tryptophan and 5-hydroxytryptophan for depressionShaw K, et al. · The Cochrane database of systematic reviews · 2002PMID 11869656 ↗04Are tryptophan and 5-hydroxytryptophan effective treatments for depression? A meta-analysisShaw K, et al. · The Australian and New Zealand journal of psychiatry · 2002PMID 12169147 ↗05Tryptophan and 5-hydroxytryptophan for depressionShaw K, et al. · The Cochrane database of systematic reviews · 2001Be the first to share what you noticed with 5-HTP for appetite control. How we calculate this.