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Adaptogenic root herb whose withanolide compounds are thought to blunt HPA-axis cortisol release; clinical trials link standardised extracts to reduced perceived stress and anxiety scores.
Chronic stress, burnout, high cortisol. Distinct from anxiety — stress is the response, anxiety is the reaction.
Also known as: Withania somnifera
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Ashwagandha in stress.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 37740662 2023 | Randomised trial | - | 12-week | Chalder Fatigue Scale | reported qualitatively (p=0.016) | Benefit |
| PMID 37740662 2023 | Randomised trial | - | 12-week | Free testosterone | reported qualitatively (p=0.048) | Benefit |
| PMID 37740662 2023 | Randomised trial | - | 12-week | Heart rate variability | reported qualitatively (p=0.003) | Benefit |
| PMID 37740662 2023 | Randomised trial | - | 12-week | Luteinizing hormone | reported qualitatively (p=0.002) | Benefit |
| PMID 37740662 2023 | Randomised trial | - | 12-week | Perceived Stress Scale | reported qualitatively (p=0.867) | No benefit |
| PMID 35984870 2022 | Randomised trial | 60 | 30 days | perceived well-being (energy, mental clarity, sleep quality, stress) | reported qualitatively | Benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Potential Bioactive Function of Microbial Metabolites as Inhibitors of Tyrosinase: A Systematic ReviewBarcenas-Giraldo S, et al. · International journal of molecular sciences · 2026PMID 41596661 ↗02Effects of ashwagandha (Withania somnifera) on mental health in adults: A systematic review and dose-response meta-analysis of randomized controlled trialsAlsanie SA, et al. · Complementary therapies in medicine · 2026PMID 41644067 ↗03Mechanism of Ganoderma lucidum polysaccharides in the mangement of diabetes and its complicationsXin Y, et al. · Frontiers in pharmacology · 2026PMID 42147328 ↗04Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional ImplicationsGong P, et al. · Molecular nutrition & food research · 2025PMID 40289452 ↗Be the first to share what you noticed with Ashwagandha for stress. How we calculate this.