About Stress — Mental Health.
Chronic stress, burnout, high cortisol. Distinct from anxiety — stress is the response, anxiety is the reaction.
Audited published research per compound. Drill into a pair for the breakdown.
Bar length counts published studies — green marks studies reporting at least one benefit, slate the other studies (no benefit, unclear or harm); labels read benefit studies / all studies.
◆ marks each compound's research score (0-100): how consistently published studies reported a benefit, weighted by study design. It summarises the research, not how well a compound will work for you.
Compounds with published trial evidence for this condition, ranked by strength of evidence. Each result is put in plain terms and comes from the study itself — open “Exact figures” for the published statistics, or follow the study link to read the paper.
| Compound | Evidence strength | What studies found |
|---|---|---|
| AshwagandhaResearch score 55/100 · Moderate | 2 randomised trials — 2 studies | 5/6 outcomes showed benefit
|
We publish community results for stress only once at least 10 people have reported on the same compound — so no individual report is ever shown. Until then, here is the research side on its own.
Used something for stress? Sharing how it went for you helps the next person — it is only ever published as part of a group of 10 or more.
Add your outcomeOpen the original papers, check their methods, and discuss what is relevant with a qualified professional.
Every study behind the numbers above is linked next to its result.
Ordered by strength of evidence, then result direction.
01Potential Bioactive Function of Microbial Metabolites as Inhibitors of Tyrosinase: A Systematic ReviewBarcenas-Giraldo S, et al. · International journal of molecular sciences · 2026Systematic Review · matched via Stress · PubMed record (CORPUS-A)
PMID 41596661 ↗02Effects of ashwagandha (Withania somnifera) on mental health in adults: A systematic review and dose-response meta-analysis of randomized controlled trialsAlsanie SA, et al. · Complementary therapies in medicine · 2026Systematic Review · matched via Stress · PubMed record (CORPUS-A)
PMID 41644067 ↗03Mechanism of Ganoderma lucidum polysaccharides in the mangement of diabetes and its complicationsXin Y, et al. · Frontiers in pharmacology · 2026Systematic Review · matched via Stress · PubMed record (CORPUS-A)
PMID 42147328 ↗04Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional ImplicationsGong P, et al. · Molecular nutrition & food research · 2025Systematic Review · matched via Stress · PubMed record (CORPUS-A)
PMID 40289452 ↗05Levodopa and Plant-Derived Bioactive Compounds in Parkinson's Disease: Mechanisms, Efficacy, and Future PerspectivesAktaş E, et al. · CNS neuroscience & therapeutics · 2025Systematic Review · matched via Stress · PubMed record (CORPUS-A)
These compounds appear in related research or traditional use. Their position is not a recommendation or ranking. Research scores summarise published studies only.
| ReishiResearch score 11/100 · Mixed/Weak | 1 randomised trial — 1 study | 1/4 outcomes showed benefit
|
Outcome summaries extracted from the linked papers' curated records. Educational, not medical advice.
Ordered by strength of evidence, then result direction.
Blunted by ~20% (600mg)
Exercising adults · Randomised trial · PMID 26491131 ↗Moderate evidenceReduced02Cortisol — ReducedReduced by 28% (300mg twice daily, 8 weeks)
Adults under chronic stress · Double-blind randomised trial · PMID 28479013 ↗Moderate evidenceReduced03Perceived stress — ReducedStress scores reduced by 44% (300mg twice daily, 8 weeks)
Adults under chronic stress · Double-blind randomised trial · PMID 28479013 ↗Moderate evidenceReducedFigures are reported as published; study designs and populations vary. Works for Us does not interpret results or provide medical advice.