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Oil pressed from Nigella sativa seeds; its active compound thymoquinone has shown anti-inflammatory and antioxidant activity in trials, and is studied for metabolic, respiratory, and immune outcomes.
Chronic systemic inflammation underlies most modern diseases — heart disease, diabetes, autoimmune conditions.
Also known as: Nigella sativa, Black cumin seed oil
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Black Seed Oil in inflammation.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 37859312 2024 | Systematic review | 1033 | - | CRP | -0.60 SMD (95% CI: from -0.96 to -0.23; P = 0.00) | Benefit |
| PMID 37859312 2024 | Systematic review | 1033 | - | IL-6 | -0.54 SMD (95% CI: from -1.01 to -0.07; P = 0.02) | Benefit |
| PMID 37859312 2024 | Systematic review | 1033 | - | MDA | -1.28 SMD (95% CI: from -2.11 to -0.46; P = 0.00) | Benefit |
| PMID 37859312 2024 | Systematic review | 1033 | - | SOD | 1.35 SMD (95% CI, from 0.77 to 1.93; P = 0.00) | Benefit |
| PMID 37859312 2024 | Systematic review | 1033 | - | TAC | 2.82 SMD (95% CI, from 0.55 to 5.084; P = 0.01) | Benefit |
| PMID 37859312 2024 | Systematic review | 1033 | - | TNF-α | -0.53 SMD (95% CI: from -0.74 to -0.53; P = 0.00) | Benefit |
| PMID 37036558 2023 | Meta-analysis | 1086 | - | glutathione peroxidase (GPx) | 1.23 SMD (95% CI 0.25, 2.22; p=0.014) | Benefit |
| PMID 37036558 2023 | Meta-analysis | 1086 | - | interleukin 6 (IL-6) | reported qualitatively (SMD=-1.13; 95% CI -2.72, 0.46, p=0.162) | No benefit |
| PMID 37036558 2023 | Meta-analysis | 1086 | - | malondialdehyde (MDA) | -2.15 SMD (95% CI -3.37, -0.93, p<0.001) | Benefit |
| PMID 37036558 2023 | Meta-analysis | 1086 | - | serum C-reactive protein (CRP) | -2.28 SMD (95% CI -3.20, -1.37, p<0.001) | Benefit |
| PMID 37036558 2023 | Meta-analysis | 1086 | - | superoxide dismutase (SOD) | 2.05 SMD (95% CI 1.22, 2.88, p<0.001) | Benefit |
| PMID 37036558 2023 | Meta-analysis | 1086 | - | total antioxidant capacity (TAC) | 2.28 SMD (95% CI 1.29, 3.27, p<0.001) | Benefit |
| PMID 37036558 2023 | Meta-analysis | 1086 | - | tumour necrosis factor α (TNFα) | -1.21 SMD (95% CI -2.15, -0.26; p=0.013) | Benefit |
| PMID 33559935 2021 | Meta-analysis | - | - | high-sensitivity C-reactive protein (hs-CRP) | -0.67 (95% CI: -1.29, -0.05) | Benefit |
| PMID 33559935 2021 | Meta-analysis | - | - | malondialdehyde (MDA) | -1.18 (95% CI: -2.24, -0.12) | Benefit |
| PMID 33559935 2021 | Meta-analysis | - | - | superoxide dismutase (SOD) | 66.30 (95% CI: 1.03, 131.57) | Benefit |
| PMID 33559935 2021 | Meta-analysis | - | - | total antioxidant capacity (TAC) | 0.35 (95% CI: 0.10, 0.59) | Benefit |
| PMID 33559935 2021 | Meta-analysis | - | - | tumor necrosis factor-alpha (TNF-α) | -2.29 (95% CI: -4.48, -0.11) | Benefit |
| PMID 34187123 2021 | Meta-analysis | 267 | - | high sensitivity C-reactive protein | reported qualitatively (95% CI=-1.98-0.03) | No benefit |
| PMID 34187123 2021 | Meta-analysis | 134 | - | Interleukin 6 (IL-6) | reported qualitatively (95% CI=-0.65 to 0.16) | No benefit |
| PMID 34187123 2021 | Meta-analysis | 179 | - | malondialdehyde | reported qualitatively (95% CI=-1.97-0.08) | No benefit |
| PMID 34187123 2021 | Meta-analysis | 88 | - | superoxide dismutase | 63.79 µ/gHb (95% CI=6.84-120.75) | Benefit |
| PMID 34187123 2021 | Meta-analysis | 232 | - | total antioxidant capacity | 0.34 mmol/L (95% CI=0.04 to 0.63) | Benefit |
| PMID 34187123 2021 | Meta-analysis | 262 | - | Tumor Necrosis Factor alpha (TNF-α) | -2.15 pg/mL (95% CI=-3.22--1.09) | Benefit |
| PMID 32394508 2020 | Meta-analysis | 50 trials | - | CRP | reported qualitatively (95% CI: -9.23, 2.01) | No benefit |
| PMID 32394508 2020 | Meta-analysis | 50 trials | - | fasting glucose | -15.18 (95% CI: -19.82, -10.55) | Benefit |
| PMID 32394508 2020 | Meta-analysis | 50 trials | - | HbA1C levels | -0.45 (95% CI: -0.66, -0.23) | Benefit |
| PMID 32394508 2020 | Meta-analysis | 50 trials | - | LDL-cholesterol | -18.45 (95% CI: -22.44, -14.94) | Benefit |
| PMID 32394508 2020 | Meta-analysis | 50 trials | - | MDA levels | reported qualitatively (95% CI: -2.18, 0.27) | No benefit |
| PMID 32394508 2020 | Meta-analysis | 50 trials | - | TAC | reported qualitatively (95% CI: 0.00, 0.63) | No benefit |
| PMID 32394508 2020 | Meta-analysis | 50 trials | - | TNF-α | reported qualitatively (95% CI: -3.23, 0.86) | No benefit |
| PMID 32394508 2020 | Meta-analysis | 50 trials | - | total cholesterol | -16.80 (95% CI: -21.04, -12.55) | Benefit |
| PMID 32394508 2020 | Meta-analysis | 50 trials | - | triglycerides | -15.73 (95% CI: -20.77, -10.69) | Benefit |
| PMID 32394508 2020 | Meta-analysis | 50 trials | - | VLDL-cholesterol | -3.72 (95% CI: -7.27, -0.18) | Benefit |
| PMID 33183658 2020 | Meta-analysis | - | - | C-reactive protein (CRP) | -0.35 SMD (95% CI: -0.59, -0.12, P < 0.001) | Benefit |
| PMID 33183658 2020 | Meta-analysis | - | - | Malondialdehyde (MDA) | -0.56 SMD (95% CI: -0.98, -0.15, P < 0.001) | Benefit |
| PMID 33183658 2020 | Meta-analysis | - | - | Total antioxidant capacity (TAC) | 0.48 SMD (95% CI: 0.09, 0.87, P = 0.01) | Benefit |
| PMID 33183658 2020 | Meta-analysis | - | - | Tumor necrosis factor-alpha (TNF-α) | reported qualitatively (95% CI: -0.70, 0.01, P = 0.05) | No benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Role of the EPA: DHA dosing ratio in omega-3 supplements on blood fatty acid profiles and inflammation: a systematic review and meta-analysisKhabir Z, et al. · Critical reviews in food science and nutrition · 2026PMID 41568426 ↗02Effectiveness of Herbal Medicines with Anti-Inflammatory, Antimicrobial, and Antioxidant Properties in Improving Oral Health and Treating Gingivitis and Periodontitis: A Systematic ReviewMalcangi G, et al. · Nutrients · 2025PMID 40077632 ↗03Effects of Nigella sativa and its constituents on inflammatory markers in ovalbumin-induced asthma model: a preclinical systematic review and meta-analysisGhobadi H, et al. · Inflammopharmacology · 2025PMID 40839182 ↗04The effect of two anti-inflammatory dietary components, omega-3 and resveratrol, on endometriosisBe the first to share what you noticed with Black Seed Oil for inflammation. How we calculate this.