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Non-intoxicating cannabinoid that modulates the endocannabinoid system indirectly and acts on serotonin 5-HT1A receptors; studied for anxiety, inflammatory pain, and sleep disruption.
Joint discomfort, inflammation, arthritis, and reduced mobility. Affects all ages, worsens with age.
Also known as: Cannabidiol, CBD
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for CBD Oil in joint pain.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 37781283 2023 | Systematic review | 117 | 4-12 weeks | pain interference scores | -1.52 (95% CI; -3.84 to 0.80, I2 = 89.59%, p = 0.20) | Unclear |
| PMID 37781283 2023 | Systematic review | 117 | 4-12 weeks | pain severity scores | -0.60 (95% CI; -1.51 to 0.31, I2 = 45.64%, p = 0.19) | Unclear |
| PMID 35637038 2022 | Randomised trial | 18 | 2 weeks | Disabilities of the Arm, Shoulder, and Hand | reported qualitatively | Benefit |
| PMID 35637038 2022 | Randomised trial | 18 | 2 weeks | Range of motion, grip, and pinch strength | reported qualitatively | No benefit |
| PMID 35637038 2022 | Randomised trial | 18 | 2 weeks | Single Assessment Numeric Evaluation | reported qualitatively | Benefit |
| PMID 35637038 2022 | Randomised trial | 18 | 2 weeks | Visual Analog Scale pain | reported qualitatively | Benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Efficacy and Safety of Anti-nerve Growth Factor Monoclonal Antibodies in Managing Chronic Musculoskeletal Pain: A Systematic Review with Network Meta-analysisAbouelella A, et al. · Drugs · 2026PMID 41880116 ↗02The effects of oral cannabidiol supplementation on blood pressure in adults: a systematic review of randomised controlled trialsRoberts A, et al. · Journal of cannabis research · 2026PMID 42321899 ↗03Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trialsSimental-Mendía M, et al. · Clinical and experimental rheumatology · 2025PMID 39212129 ↗04A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA)Be the first to share what you noticed with CBD Oil for joint pain. How we calculate this.