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About Joint Pain — Physical Health.
Joint discomfort, inflammation, arthritis, and reduced mobility. Affects all ages, worsens with age.
Audited published research per compound. Drill into a pair for the breakdown.
Bar length counts published studies — green marks studies reporting at least one benefit, slate the other studies (no benefit, unclear or harm); labels read benefit studies / all studies.
◆ marks each compound's research score (0-100): how consistently published studies reported a benefit, weighted by study design. It summarises the research, not how well a compound will work for you.
Compounds with published trial evidence for this condition, ranked by strength of evidence. Each result is put in plain terms and comes from the study itself — open “Exact figures” for the published statistics, or follow the study link to read the paper.
| Compound | Evidence strength | What studies found |
|---|---|---|
| Hyaluronic AcidResearch score 70/100 · Strong | 3 systematic reviews/meta-analyses — 3 studies | 7/8 outcomes showed benefit
|
We publish community results for joint pain only once at least 10 people have reported on the same compound — so no individual report is ever shown. Until then, here is the research side on its own.
Used something for joint pain? Sharing how it went for you helps the next person — it is only ever published as part of a group of 10 or more.
Add your outcomeOpen the original papers, check their methods, and discuss what is relevant with a qualified professional.
Every study behind the numbers above is linked next to its result.
Ordered by strength of evidence, then result direction.
01Efficacy and Safety of Anti-nerve Growth Factor Monoclonal Antibodies in Managing Chronic Musculoskeletal Pain: A Systematic Review with Network Meta-analysisAbouelella A, et al. · Drugs · 2026Systematic Review · matched via Joint Pain · PubMed record (CORPUS-A)
PMID 41880116 ↗02Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trialsSimental-Mendía M, et al. · Clinical and experimental rheumatology · 2025Meta-Analysis · matched via Joint Pain · PubMed record (CORPUS-A)
PMID 39212129 ↗03A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA)Du D, et al. · Journal of orthopaedic surgery and research · 2025Systematic Review · matched via Joint Pain · PubMed record (CORPUS-A)
PMID 39819683 ↗04Efficacy of dietary supplements for treating knee osteoarthritis: a systematic review and network meta-analysisDu P, et al. · Frontiers in nutrition · 2025Systematic Review · matched via Joint Pain · open-access full text · PubMed record (CORPUS-A)
PMID 40123938 ↗05Stem cell injections for osteoarthritis of the kneeWhittle SL, et al. · The Cochrane database of systematic reviews · 2025These compounds appear in related research or traditional use. Their position is not a recommendation or ranking. Research scores summarise published studies only.
| CBD OILResearch score 21/100 · Mixed/Weak | 1 systematic review/meta-analysis + 1 randomised trial — 2 studies | 3/6 outcomes showed benefit
|
| GingerResearch score 21/100 · Mixed/Weak | 1 systematic review/meta-analysis + 1 randomised trial — 2 studies | 3/8 outcomes showed benefit
|
| MSMResearch score 18/100 · Mixed/Weak | 1 systematic review/meta-analysis + 1 randomised trial — 2 studies | 1/4 outcomes showed benefit
|
| Turmeric CurcuminResearch score 41/100 · Limited | 1 systematic review/meta-analysis + 1 randomised trial — 2 studies | 5/8 outcomes showed benefit
|
| Omega 3Research score 10/100 · Mixed/Weak | 1 systematic review/meta-analysis — 1 study | 1/5 outcomes showed benefit
|
| Collagen PeptidesResearch score 27/100 · Mixed/Weak | 1 randomised trial — 1 study | 3/5 outcomes showed benefit
|
| GlucosamineResearch score 0/100 · Mixed/Weak | 1 randomised trial — 1 study | 0/4 outcomes showed benefit
|
Systematic Review · matched via Joint Pain · PubMed record (CORPUS-A)
Outcome summaries extracted from the linked papers' curated records. Educational, not medical advice.
Ordered by strength of evidence, then result direction.
Reduced with high-dose omega-3s
Rheumatoid arthritis patients · Meta-analysis · PMID 17128924 ↗Strong evidenceReduced02Osteoarthritis pain — ReducedModest reduction, especially knee OA
Osteoarthritis patients · Meta-analysis · PMID 23720589 ↗Strong evidenceReduced03Knee osteoarthritis pain — ReducedTurmeric extract as effective as ibuprofen over 4 weeks
Knee osteoarthritis patients · Randomised controlled trial · PMID 25342816 ↗Moderate evidenceReducedFigures are reported as published; study designs and populations vary. Works for Us does not interpret results or provide medical advice.