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Long-chain polyunsaturated fatty acids from fish or algal oil that are incorporated into cell membranes and reduce pro-inflammatory eicosanoid production; linked to cardiovascular, joint, and neurological benefits.
Joint discomfort, inflammation, arthritis, and reduced mobility. Affects all ages, worsens with age.
Also known as: Fish Oil, Krill Oil, EPA, DHA
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Omega-3 (EPA/DHA) in joint pain.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 22835600 2012 | Meta-analysis | - | 3 months | Morning stiffness | -0.224 standardized mean difference (95% CI-0.955-0.212, p = 0.221) | No benefit |
| PMID 22835600 2012 | Meta-analysis | - | 3 months | NSAID consumption | -0.518 standardized mean difference (95% CI -0.915 to -0.121, p = 0.011) | Benefit |
| PMID 22835600 2012 | Meta-analysis | - | 3 months | Physical function | 0.264 standardized mean difference (95% CI-0.232-0.724, p = 0.314) | No benefit |
| PMID 22835600 2012 | Meta-analysis | - | 3 months | Swollen joint count | -0.170 standardized mean difference (95% CI-0.454-0.114, p = 0.241) | No benefit |
| PMID 22835600 2012 | Meta-analysis | - | 3 months | Tender joint count | -0.214 standardized mean difference (95% CI-0.489-0.062, p = 0.128) | No benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Role of the EPA: DHA dosing ratio in omega-3 supplements on blood fatty acid profiles and inflammation: a systematic review and meta-analysisKhabir Z, et al. · Critical reviews in food science and nutrition · 2026PMID 41568426 ↗02Efficacy and Safety of Anti-nerve Growth Factor Monoclonal Antibodies in Managing Chronic Musculoskeletal Pain: A Systematic Review with Network Meta-analysisAbouelella A, et al. · Drugs · 2026PMID 41880116 ↗03Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trialsSimental-Mendía M, et al. · Clinical and experimental rheumatology · 2025PMID 39212129 ↗04A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA)Be the first to share what you noticed with Omega-3 (EPA/DHA) for joint pain. How we calculate this.