Chronic Pain

About Chronic Pain — Physical Health.

Persistent pain lasting longer than 3 months. Can stem from injury, inflammation, or nervous system dysfunction.

2studies analysed

1compounds with evidence

Systematic reviewstrongest evidence

Where research is strongest

Cannabis THC 22

5linked compounds

10linked studies

0published community reports

On this pageBy the numbers Community outcomes Research Compounds

Evidence analytics

Where the evidence is concentrated.

Audited published research per compound. Drill into a pair for the breakdown.

Bar length counts published studies — green marks studies reporting at least one benefit, slate the other studies (no benefit, unclear or harm); labels read benefit studies / all studies.

Studies reporting a benefit
Other studies
◆ Research score (0-100)

◆ marks each compound's research score (0-100): how consistently published studies reported a benefit, weighted by study design. It summarises the research, not how well a compound will work for you.

Degree of benefit: what studies found for Chronic Pain

Compounds with published trial evidence for this condition, ranked by strength of evidence. Each result is put in plain terms and comes from the study itself — open “Exact figures” for the published statistics, or follow the study link to read the paper.

Compound	Evidence strength	What studies found
Cannabis THCResearch score 22/100 · Mixed/Weak	2 systematic reviews/meta-analyses — 2 studies	5/15 outcomes showed benefit 30% or greater pain relief39% vs 33% of participants — 6 more per 100 in the compound groupbenefit2018 study ↗ Exact figures 39% versus 33% (95% CI 0.03 to 0.15) n=1586 participants · PMID 29513392 50% or greater pain relief21% vs 17% of participants — 4 more per 100 in the compound groupbenefit2018 study ↗ Exact figures 21% versus 17% (95% CI 0.00 to 0.09) n=1001 participants · PMID 29513392 Pain severity and overall function

Community outcomes

No community reports published yet.

We publish community results for chronic pain only once at least 10 people have reported on the same compound — so no individual report is ever shown. Until then, here is the research side on its own.

Cannabis THC
Research saysResearch score 22/100 · Mixed/Weak2 of 2 studies reported at least one benefit
People reportNot published yet — needs 10 or more reports

Used something for chronic pain? Sharing how it went for you helps the next person — it is only ever published as part of a group of 10 or more.

Add your outcome

Peer-reviewed research

Keep evidence in the room.

Open the original papers, check their methods, and discuss what is relevant with a qualified professional.

Every study behind the numbers above is linked next to its result.

8 more papers on chronic pain not summarised above

Ordered by strength of evidence, then result direction.

01Cannabis-Based Products for Chronic Pain : An Updated Systematic ReviewChou R, et al. · Annals of internal medicine · 2026

Systematic Review · matched via Chronic Pain · PubMed record (CORPUS-A)

PMID 41429020 ↗02Effectiveness of Cannabidiol to Manage Chronic Pain: A Systematic ReviewMohammed SYM, et al. · Pain management nursing : official journal of the American Society of Pain Management Nurses · 2024

Systematic Review · matched via Chronic Pain · PubMed record (CORPUS-A)

PMID 37953193 ↗03Evidence-Based Treatment of Pain in Chemotherapy-Induced Peripheral NeuropathyD'Souza RS, et al. · Current pain and headache reports · 2023

Systematic Review · matched via Chronic Pain · PubMed record (CORPUS-A)

PMID 37058254 ↗04Cannabis and cannabinoids for symptomatic treatment for people with multiple sclerosisFilippini G, et al. · The Cochrane database of systematic reviews · 2022

Systematic Review · matched via Chronic Pain · PubMed record (CORPUS-A)

PMID 35510826 ↗05Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indicationsBilbao A, et al. · BMC medicine · 2022

Meta-Analysis · matched via Chronic Pain · PubMed record (CORPUS-A)

PMID 35982439 ↗

Linked compounds

Browse every linked compound.

These compounds appear in related research or traditional use. Their position is not a recommendation or ranking. Research scores summarise published studies only.

Botanical