Organic sulphur compound providing a bioavailable sulphur source for collagen and keratin synthesis; studied for joint pain, exercise-induced muscle soreness, and allergy symptoms, usually alongside glucosamine.
Persistent pain lasting longer than 3 months. Can stem from injury, inflammation, or nervous system dysfunction.
Also known as: MSM, Organic sulphur
Every published result for this pair, extracted and audited.
Research volume over time for MSM (Methylsulfonylmethane) × chronic pain. Structured outcome extraction (direction, effect size) for this pair is in progress - the full analytics will appear here once audited.
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Cannabis-Based Products for Chronic Pain : An Updated Systematic ReviewChou R, et al. · Annals of internal medicine · 2026PMID 41429020 ↗02Efficacy and Safety of Anti-nerve Growth Factor Monoclonal Antibodies in Managing Chronic Musculoskeletal Pain: A Systematic Review with Network Meta-analysisAbouelella A, et al. · Drugs · 2026PMID 41880116 ↗03Efficacy of dietary supplements for treating knee osteoarthritis: a systematic review and network meta-analysisDu P, et al. · Frontiers in nutrition · 2025PMID 40123938 ↗04Effectiveness of Cannabidiol to Manage Chronic Pain: A Systematic ReviewMohammed SYM, et al. · Pain management nursing : official journal of the American Society of Pain Management Nurses · 2024PMID 37953193 ↗Be the first to share what you noticed with MSM (Methylsulfonylmethane) for chronic pain. How we calculate this.