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Amino sugar naturally present in cartilage, used as a substrate for glycosaminoglycan synthesis; sulfate-bound formulations have the strongest trial evidence for slowing osteoarthritis symptom progression over months of use.
Joint discomfort, inflammation, arthritis, and reduced mobility. Affects all ages, worsens with age.
Also known as: Glucosamine sulfate, Glucosamine HCl
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Glucosamine in joint pain.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 25589511 2016 | Randomised trial | 606 | 6 months | Adverse events (6 months) | reported qualitatively | No benefit |
| PMID 25589511 2016 | Randomised trial | 606 | 6 months | Joint swelling and effusion (6 months) | >50% | Unclear |
| PMID 25589511 2016 | Randomised trial | 606 | 6 months | OMERACT-OARSI response criteria (6 months) | 79.7% | Unclear |
| PMID 25589511 2016 | Randomised trial | 606 | 6 months | WOMAC pain (6 months) | -1.11 (-22.0 to 19.8; p=0.92) | Unclear |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Efficacy and Safety of Anti-nerve Growth Factor Monoclonal Antibodies in Managing Chronic Musculoskeletal Pain: A Systematic Review with Network Meta-analysisAbouelella A, et al. · Drugs · 2026PMID 41880116 ↗02Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trialsSimental-Mendía M, et al. · Clinical and experimental rheumatology · 2025PMID 39212129 ↗03A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA)Du D, et al. · Journal of orthopaedic surgery and research · 2025PMID 39819683 ↗04Efficacy of dietary supplements for treating knee osteoarthritis: a systematic review and network meta-analysisBe the first to share what you noticed with Glucosamine for joint pain. How we calculate this.