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Glycosaminoglycan naturally present in skin, joint synovial fluid, and connective tissue, capable of binding many times its weight in water; oral and injectable forms are studied for skin hydration and joint lubrication.
Joint discomfort, inflammation, arthritis, and reduced mobility. Affects all ages, worsens with age.
Also known as: HA, Sodium hyaluronate
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Hyaluronic Acid in joint pain.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 37314014 2023 | Systematic review | - | - | pain relief | reported qualitatively | Benefit |
| PMID 37314198 2023 | Meta-analysis | 1023 | - | pain relief (VAS) comparing HA vs corticosteroid injections | reported qualitatively (p=0.002) | Benefit |
| PMID 37314198 2023 | Meta-analysis | 1023 | - | pain relief (VAS/NRS) comparing HA+PT vs PT alone | 4.43 ES (p=0.00006) | Benefit |
| PMID 32278352 2020 | Meta-analysis | 941 | - | Adverse events | reported qualitatively (P>0.05) | No benefit |
| PMID 32278352 2020 | Meta-analysis | 941 | 6 months | Lequesne Index | -0.42 SMD (95% CI: -0.67 to -0.17; P<0.05) | Benefit |
| PMID 32278352 2020 | Meta-analysis | 941 | 6 months | VAS for pain | -0.31 SMD (95% CI: -0.55 to -0.06; P=0.01<0.05) | Benefit |
| PMID 32278352 2020 | Meta-analysis | 941 | 12 months | WOMAC Function Score | -0.32 SMD (95% CI: -0.54 to -0.10; P<0.05) | Benefit |
| PMID 32278352 2020 | Meta-analysis | 941 | 12 months | WOMAC Total Score | -0.42 SMD (95% CI: -0.67 to -0.17; P<0.05) | Benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Efficacy and Safety of Anti-nerve Growth Factor Monoclonal Antibodies in Managing Chronic Musculoskeletal Pain: A Systematic Review with Network Meta-analysisAbouelella A, et al. · Drugs · 2026PMID 41880116 ↗02Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trialsSimental-Mendía M, et al. · Clinical and experimental rheumatology · 2025PMID 39212129 ↗03A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA)Du D, et al. · Journal of orthopaedic surgery and research · 2025PMID 39819683 ↗04Efficacy of dietary supplements for treating knee osteoarthritis: a systematic review and network meta-analysisBe the first to share what you noticed with Hyaluronic Acid for joint pain. How we calculate this.