Non-intoxicating cannabinoid that modulates the endocannabinoid system indirectly and acts on serotonin 5-HT1A receptors; studied for anxiety, inflammatory pain, and sleep disruption.
Difficulty falling asleep, staying asleep, or poor sleep quality. Insomnia affects ~30% of adults.
Also known as: Cannabidiol, CBD
Every published result for this pair, extracted and audited.
Research volume over time for CBD Oil × sleep issues. Structured outcome extraction (direction, effect size) for this pair is in progress - the full analytics will appear here once audited.
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01The effects of oral cannabidiol supplementation on blood pressure in adults: a systematic review of randomised controlled trialsRoberts A, et al. · Journal of cannabis research · 2026PMID 42321899 ↗02Dysregulation of melatonin rhythm in Parkinson's and Huntington's disease: a systematic review and meta-analysisSuram RP, et al. · Frontiers in aging neuroscience · 2025PMID 41143249 ↗03Effectiveness of Cannabidiol to Manage Chronic Pain: A Systematic ReviewMohammed SYM, et al. · Pain management nursing : official journal of the American Society of Pain Management Nurses · 2024PMID 37953193 ↗04Therapeutic potential of cannabidiol (CBD) in anxiety disorders: A systematic review and meta-analysisHan K, et al. · Psychiatry research · 2024PMID 38924898 ↗Be the first to share what you noticed with CBD Oil for sleep issues. How we calculate this.