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Fat-soluble compound essential to mitochondrial ATP production and antioxidant defence; levels decline with age and statin use, so supplementation is studied for statin-associated muscle symptoms and cardiovascular support.
Chronic tiredness, low energy, and exhaustion not explained by other medical conditions.
Also known as: CoQ10, Ubiquinone, Ubiquinol
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Coenzyme Q10 in fatigue.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 37764774 2023 | Systematic review | - | - | anaerobic performance | reported qualitatively | Benefit |
| PMID 37764774 2023 | Systematic review | - | - | antioxidant activity | reported qualitatively | Benefit |
| PMID 37764774 2023 | Systematic review | - | - | fatigue indicators (Creatine Kinase) | reported qualitatively | Benefit |
| PMID 37764774 2023 | Systematic review | - | - | liver damage markers (ALT, AST, γGT) | reported qualitatively | Benefit |
| PMID 37764774 2023 | Systematic review | - | - | oxidative stress markers | reported qualitatively | Benefit |
| PMID 36091835 2022 | Systematic review | 1,126 | - | fatigue scores | -0.398 Hedges' g (95% confidence interval = -0.641 to -0.155, p = 0.001) | Benefit |
| PMID 34444817 2021 | Randomised trial | 207 | 12 weeks | cognitive fatigue perception | reported qualitatively (p < 0.001) | Benefit |
| PMID 34444817 2021 | Randomised trial | 207 | 8 weeks | habitual sleep efficiency | reported qualitatively (p = 0.038) | Benefit |
| PMID 34444817 2021 | Randomised trial | 207 | 12 weeks | health-related quality of life (SF-36) | reported qualitatively (p < 0.05) | Benefit |
| PMID 34444817 2021 | Randomised trial | 207 | 12 weeks | overall FIS-40 score | reported qualitatively (p = 0.022) | Benefit |
| PMID 34444817 2021 | Randomised trial | 207 | 4 weeks | sleep duration | reported qualitatively (p = 0.018) | Benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Differences in Ferritin, Vitamin D, and Vitamin B12 Between Fibromyalgia Patients and Healthy Individuals: A Systematic Review and Meta-AnalysisIsmail O, et al. · Musculoskeletal care · 2025PMID 39832803 ↗02Ferric Carboxymaltose (FCM)-Associated Hypophosphatemia (HPP): A Systematic ReviewMagagnoli J, et al. · American journal of hematology · 2025PMID 39935027 ↗03Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic ReviewDorczok MC, et al. · Nutrients · 2025PMID 39940333 ↗04Role of vitamin D as adjuvant therapy on multiple sclerosis: an updated systematic review and meta-analysis of randomized controlled trialsSerag I, et al. · European journal of medical research · 2025PMID 40797337 ↗Be the first to share what you noticed with Coenzyme Q10 for fatigue. How we calculate this.