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About Fatigue — General Health.
Chronic tiredness, low energy, and exhaustion not explained by other medical conditions.
Audited published research per compound. Drill into a pair for the breakdown.
Bar length counts published studies — green marks studies reporting at least one benefit, slate the other studies (no benefit, unclear or harm); labels read benefit studies / all studies.
◆ marks each compound's research score (0-100): how consistently published studies reported a benefit, weighted by study design. It summarises the research, not how well a compound will work for you.
Compounds with published trial evidence for this condition, ranked by strength of evidence. Each result is put in plain terms and comes from the study itself — open “Exact figures” for the published statistics, or follow the study link to read the paper.
| Compound | Evidence strength | What studies found |
|---|---|---|
| Coq10Research score 74/100 · Strong | 2 systematic reviews/meta-analyses + 1 randomised trial — 3 studies | 11/11 outcomes showed benefit
|
We publish community results for fatigue only once at least 10 people have reported on the same compound — so no individual report is ever shown. Until then, here is the research side on its own.
Used something for fatigue? Sharing how it went for you helps the next person — it is only ever published as part of a group of 10 or more.
Add your outcomeOpen the original papers, check their methods, and discuss what is relevant with a qualified professional.
Every study behind the numbers above is linked next to its result.
Ordered by strength of evidence, then result direction.
01Differences in Ferritin, Vitamin D, and Vitamin B12 Between Fibromyalgia Patients and Healthy Individuals: A Systematic Review and Meta-AnalysisIsmail O, et al. · Musculoskeletal care · 2025Systematic Review · matched via Fatigue · PubMed record (CORPUS-A)
PMID 39832803 ↗02Ferric Carboxymaltose (FCM)-Associated Hypophosphatemia (HPP): A Systematic ReviewMagagnoli J, et al. · American journal of hematology · 2025Systematic Review · matched via Fatigue · PubMed record (CORPUS-A)
PMID 39935027 ↗03Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic ReviewDorczok MC, et al. · Nutrients · 2025Systematic Review · matched via Fatigue · PubMed record (CORPUS-A)
PMID 39940333 ↗04Role of vitamin D as adjuvant therapy on multiple sclerosis: an updated systematic review and meta-analysis of randomized controlled trialsSerag I, et al. · European journal of medical research · 2025Meta-Analysis · matched via Fatigue · PubMed record (CORPUS-A)
PMID 40797337 ↗05Psychiatric and cognitive outcomes of iron supplementation in non-anemic children, adolescents, and menstruating adults: A meta-analysis and systematic reviewFiani D, et al. · Neuroscience and biobehavioral reviews · 2025These compounds appear in related research or traditional use. Their position is not a recommendation or ranking. Research scores summarise published studies only.
| IronResearch score 30/100 · Mixed/Weak | 1 systematic review/meta-analysis — 1 study | 3/5 outcomes showed benefit
|
| Rhodiola RoseaResearch score 41/100 · Limited | 3 randomised trials — 3 studies | 4/8 outcomes showed benefit
|
| ShilajitResearch score 44/100 · Limited | 1 randomised trial — 1 study | 2/2 outcomes showed benefit
|
| Vitamin D3Research score 44/100 · Limited | 1 randomised trial — 1 study | 2/2 outcomes showed benefit
|
Systematic Review · matched via Fatigue · PubMed record (CORPUS-A)
Outcome summaries extracted from the linked papers' curated records. Educational, not medical advice.
Ordered by strength of evidence, then result direction.
Significantly reduced over 12 weeks
Adults with burnout · Randomised controlled trial · PMID 19649319 ↗Moderate evidenceReduced02Mental fatigue — ReducedReduced; cognitive performance improved (5g daily)
Vegetarians · Randomised controlled trial · PMID 23416054 ↗Moderate evidenceReduced03Fatigue — ImprovedSymptoms improved after correcting deficiency
Vitamin-D-deficient primary-care patients · Cross-sectional study · PMID 23760026 ↗Weak evidenceImprovedFigures are reported as published; study designs and populations vary. Works for Us does not interpret results or provide medical advice.