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Essential mineral forming the oxygen-binding core of haemoglobin and myoglobin; supplementation corrects iron-deficiency anaemia, a common cause of fatigue, particularly in menstruating women.
Chronic tiredness, low energy, and exhaustion not explained by other medical conditions.
Also known as: Ferrous sulfate, Ferrous bisglycinate
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Iron in fatigue.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 29626044 2018 | Systematic review | 235 | - | maximal oxygen consumption | reported qualitatively (95% CI -0.15 to 0.37) | No benefit |
| PMID 29626044 2018 | Systematic review | 714 | - | self-reported fatigue | -0.38 SMD (95% CI -0.52 to -0.23) | Benefit |
| PMID 29626044 2018 | Systematic review | 616 | - | serum ferritin | 9.23 µmol/L (95% CI 6.48 to 11.97) | Benefit |
| PMID 29626044 2018 | Systematic review | 298 | - | serum haemoglobin concentration | 4.01 g/L (95% CI 1.22 to 6.81) | Benefit |
| PMID 29626044 2018 | Systematic review | - | - | timed methods of exercise testing | reported qualitatively | No benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Differences in Ferritin, Vitamin D, and Vitamin B12 Between Fibromyalgia Patients and Healthy Individuals: A Systematic Review and Meta-AnalysisIsmail O, et al. · Musculoskeletal care · 2025PMID 39832803 ↗02Ferric Carboxymaltose (FCM)-Associated Hypophosphatemia (HPP): A Systematic ReviewMagagnoli J, et al. · American journal of hematology · 2025PMID 39935027 ↗03Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic ReviewDorczok MC, et al. · Nutrients · 2025PMID 39940333 ↗04Role of vitamin D as adjuvant therapy on multiple sclerosis: an updated systematic review and meta-analysis of randomized controlled trialsSerag I, et al. · European journal of medical research · 2025PMID 40797337 ↗Be the first to share what you noticed with Iron for fatigue. How we calculate this.