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Adaptogenic root native to arctic Scandinavia and Siberia; its rosavins and salidroside are thought to modulate cortisol and monoamine activity, with trials showing reduced fatigue and improved stress resilience.
Chronic tiredness, low energy, and exhaustion not explained by other medical conditions.
Also known as: Golden Root, Arctic Root
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Rhodiola Rosea in fatigue.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 25268730 2014 | Randomised trial | 48 | day 42 | Adverse events | reported qualitatively | No benefit |
| PMID 25268730 2014 | Randomised trial | 48 | day 42 | Fatigue (VAS-F) at day 42 | 1.9 (95% CI 0.4, 3.5; p = 0.015) | Harm / risk |
| PMID 25268730 2014 | Randomised trial | 48 | day 42 | Vitality subscale (RAND-36) at day 42 | -17.3 (95% CI -30.6, -3.9; p = 0.011) | Harm / risk |
| PMID 19016404 2009 | Randomised trial | 60 | 28 days | attention (CCPT II indices: omissions, Hit RT SE, variability) | reported qualitatively | Benefit |
| PMID 19016404 2009 | Randomised trial | 60 | 28 days | burnout symptoms (Pines' burnout scale) | reported qualitatively | Benefit |
| PMID 19016404 2009 | Randomised trial | 60 | 28 days | cortisol response to awakening stress | reported qualitatively | Benefit |
| PMID 19016404 2009 | Randomised trial | 60 | 28 days | mental health (SF-36) and depression (MADRS) | reported qualitatively | No benefit |
| PMID 11081987 2000 | Randomised trial | 56 | two weeks | Mental performance / Fatigue Index tests after night duty | reported qualitatively | Benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Differences in Ferritin, Vitamin D, and Vitamin B12 Between Fibromyalgia Patients and Healthy Individuals: A Systematic Review and Meta-AnalysisIsmail O, et al. · Musculoskeletal care · 2025PMID 39832803 ↗02Ferric Carboxymaltose (FCM)-Associated Hypophosphatemia (HPP): A Systematic ReviewMagagnoli J, et al. · American journal of hematology · 2025PMID 39935027 ↗03Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic ReviewDorczok MC, et al. · Nutrients · 2025PMID 39940333 ↗04Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-AnalysisUrata M, et al. · Neuropsychopharmacology reports · 2025PMID 40014460 ↗Be the first to share what you noticed with Rhodiola Rosea for fatigue. How we calculate this.