Loading…
Compound stored in skeletal muscle as phosphocreatine, buffering ATP regeneration during short, high-intensity effort; one of the most extensively studied ergogenic supplements for strength and lean mass.
Memory, mental clarity, and overall brain health. Critical for healthy ageing and peak performance.
Also known as: Creatine
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Creatine Monohydrate in cognitive function.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 35984306 2023 | Meta-analysis | - | 5 days to 24 weeks | memory performance (older adults) | 0.88 SMD (95%CI, 0.22-1.55; P=0.009) | Benefit |
| PMID 35984306 2023 | Meta-analysis | - | 5 days to 24 weeks | memory performance (overall) | 0.29 SMD (95%CI, 0.04-0.53; P=0.02) | Benefit |
| PMID 35984306 2023 | Meta-analysis | - | 5 days to 24 weeks | memory performance (younger counterparts) | reported qualitatively (95%CI, -0.14 to 0.20; P=0.72) | No benefit |
| PMID 37968687 2023 | Randomised trial | 123 | 6 weeks | Backward Digit Span (BDS) | 0.029 η²P (p=0.064) | Unclear |
| PMID 37968687 2023 | Randomised trial | 123 | 6 weeks | Exploratory cognitive tasks | reported qualitatively | No benefit |
| PMID 37968687 2023 | Randomised trial | 123 | 6 weeks | Raven's Advanced Progressive Matrices (RAPM) | 0.008 η²P (p=0.327) | No benefit |
| PMID 37968687 2023 | Randomised trial | 123 | 6 weeks | Side effects | 4.25 RR (p=0.002) | Harm / risk |
| PMID 21118604 2011 | Randomised trial | 128 | 5 d | Memory in vegetarians | reported qualitatively | Benefit |
| PMID 21118604 2011 | Randomised trial | 128 | 5 d | Reaction-time variability | reported qualitatively | Benefit |
| PMID 21118604 2011 | Randomised trial | 128 | 5 d | Verbal fluency and vigilance | reported qualitatively | No benefit |
| PMID 17828627 2007 | Randomised trial | 15 | 1 week | backward number recall | reported qualitatively | No benefit |
| PMID 17828627 2007 | Randomised trial | 15 | 1 week | cognitive performance (random number generation, forward number/spatial recall, long-term memory tasks) | reported qualitatively | Benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Ginkgo biloba for cognitive impairment and dementiaWieland LS, et al. · The Cochrane database of systematic reviews · 2026PMID 41641880 ↗02Effects of acute exercise on cognitive function: A meta-review of 30 systematic reviews with meta-analysesChang YK, et al. · Psychological bulletin · 2025PMID 39883421 ↗03Ginkgo biloba extract EGb 761 is safe and effective in the treatment of mild dementia - a meta-analysis of patient subgroups in randomised controlled trialsRiepe M, et al. · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2025PMID 39895346 ↗04Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysisAmanat S, et al. · Advances in nutrition (Bethesda, Md.) · 2025PMID 40355028 ↗Be the first to share what you noticed with Creatine Monohydrate for cognitive function. How we calculate this.