Compound library
Understand what people are taking.
Browse medicines, supplements, herbs, and health foods. Each profile brings community reports and linked research into one clear view.
Browse medicines, supplements, herbs, and health foods. Each profile brings community reports and linked research into one clear view.
The simplest amino acid: an inhibitory brain messenger and a building block of collagen and glutathione. Human evidence is thin. Small trials report better sleep and less next-day tiredness with 3 g at bedtime, and one 74-person trial lowered HbA1c in type 2 diabetes, but a 2024 systematic review rates the sleep studies as small with a high risk of bias. 'GlyNAC' trials combine it with NAC, so they cannot show what glycine does alone.
5 of 6 results reported a benefit, from 3 published studies.
3 studies, including a review of trials
These are the figures the studies reported, not a prediction for any one person. Where several studies measured the same thing in the same unit, we show a simple average and say so. Every individual result is listed below.
See every resultDifficulty falling asleep, staying asleep, or poor sleep quality. Insomnia affects ~30% of adults.
Also known as: Glycine supplement
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Glycine in sleep issues.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 37851316 2024 | Systematic review | - | - | Sleep in healthy adults (small studies, high risk of bias) | reported qualitatively | Benefit |
| PMID 42687500 2026 | Other | - | - | Circulating glycine after glycine-containing supplements | reported qualitatively | Benefit |
| PMID 42687500 2026 | Other | - | - | Sleep-related outcomes in oral glycine trials | reported qualitatively | Benefit |
| PMID 22529837 2012 | Other | - | - | Daytime fatigue after partial sleep restriction | reported qualitatively | Benefit |
| PMID 22529837 2012 | Other | - | - | Daytime sleepiness after partial sleep restriction | reported qualitatively | Unclear |
| PMID 22529837 2012 | Other | - | - | Psychomotor vigilance test performance | reported qualitatively | Benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01The effects of oral cannabidiol supplementation on blood pressure in adults: a systematic review of randomised controlled trialsRoberts A, et al. · Journal of cannabis research · 2026PMID 42321899 ↗02Dysregulation of melatonin rhythm in Parkinson's and Huntington's disease: a systematic review and meta-analysisSuram RP, et al. · Frontiers in aging neuroscience · 2025PMID 41143249 ↗03Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic ReviewGonzález-Parejo P, et al. · Nutrients · 2024PMID 39064758 ↗04Sleep disturbances and female infertility: a systematic reviewLi J, et al. · BMC women's health · 2024PMID 39707272 ↗05The Role of Magnesium in Sleep Health: a Systematic Review of Available LiteratureBe the first to share what you noticed with Glycine for sleep issues. Why counts start empty.