Amino acid from tea leaves that crosses the blood-brain barrier and increases alpha-wave brain activity; promotes calm alertness without sedation, often paired with caffeine.
Difficulty falling asleep, staying asleep, or poor sleep quality. Insomnia affects ~30% of adults.
Also known as: Theanine, L-gamma-glutamylethylamide
Every published result for this pair, extracted and audited.
Research volume over time for L-Theanine × sleep issues. Structured outcome extraction (direction, effect size) for this pair is in progress - the full analytics will appear here once audited.
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01The effects of oral cannabidiol supplementation on blood pressure in adults: a systematic review of randomised controlled trialsRoberts A, et al. · Journal of cannabis research · 2026PMID 42321899 ↗02Dysregulation of melatonin rhythm in Parkinson's and Huntington's disease: a systematic review and meta-analysisSuram RP, et al. · Frontiers in aging neuroscience · 2025PMID 41143249 ↗03Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic ReviewGonzález-Parejo P, et al. · Nutrients · 2024PMID 39064758 ↗04The effects of L-theanine supplementation on the outcomes of patients with mental disorders: a systematic reviewMoshfeghinia R, et al. · BMC psychiatry · 2024PMID 39633316 ↗Be the first to share what you noticed with L-Theanine for sleep issues. How we calculate this.