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Medicinal mushroom containing hericenones and erinacines that stimulate nerve growth factor (NGF) synthesis in animal models; studied in humans for mild cognitive impairment and mood.
Memory, mental clarity, and overall brain health. Critical for healthy ageing and peak performance.
Also known as: Hericium erinaceus, Yamabushitake
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Lion's Mane Mushroom in cognitive function.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 38004235 2023 | Randomised trial | 41 | 60 min post dose | Stroop task performance speed | reported qualitatively (p = 0.005) | Benefit |
| PMID 38004235 2023 | Randomised trial | 41 | 28-day supplementation | Subjective stress | reported qualitatively (p = 0.051) | No benefit |
| PMID 31413233 2019 | Randomised trial | - | 12 weeks | Mini Mental State Examination (MMSE) | reported qualitatively | Benefit |
| PMID 18844328 2009 | Randomised trial | 30 | 16 weeks | cognitive function scale (HDS-R based), weeks 8-16 of treatment | reported qualitatively | Benefit |
| PMID 18844328 2009 | Randomised trial | 30 | 4 weeks | cognitive function scale, 4 weeks after stopping treatment | reported qualitatively | No benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Ginkgo biloba for cognitive impairment and dementiaWieland LS, et al. · The Cochrane database of systematic reviews · 2026PMID 41641880 ↗02Effects of acute exercise on cognitive function: A meta-review of 30 systematic reviews with meta-analysesChang YK, et al. · Psychological bulletin · 2025PMID 39883421 ↗03Ginkgo biloba extract EGb 761 is safe and effective in the treatment of mild dementia - a meta-analysis of patient subgroups in randomised controlled trialsRiepe M, et al. · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2025PMID 39895346 ↗04Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysisAmanat S, et al. · Advances in nutrition (Bethesda, Md.) · 2025PMID 40355028 ↗Be the first to share what you noticed with Lion's Mane Mushroom for cognitive function. How we calculate this.