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Long-chain polyunsaturated fatty acids from fish or algal oil that are incorporated into cell membranes and reduce pro-inflammatory eicosanoid production; linked to cardiovascular, joint, and neurological benefits.
Chronic systemic inflammation underlies most modern diseases — heart disease, diabetes, autoimmune conditions.
Also known as: Fish Oil, Krill Oil, EPA, DHA
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Omega-3 (EPA/DHA) in inflammation.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 35914448 2022 | Meta-analysis | - | - | interleukin 6 (IL-6) | -0.22 (95% CI: -0.39, -0.05, p=0.010) | Benefit |
| PMID 35914448 2022 | Meta-analysis | - | - | serum C-reactive protein (CRP) | -0.40 (95% CI: -0.56, -0.24, p<0.001) | Benefit |
| PMID 35914448 2022 | Meta-analysis | - | - | Tumour necrosis factor α (TNFα) | -0.23 (95% CI: -0.37, -0.08, p=0.002) | Benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Role of the EPA: DHA dosing ratio in omega-3 supplements on blood fatty acid profiles and inflammation: a systematic review and meta-analysisKhabir Z, et al. · Critical reviews in food science and nutrition · 2026PMID 41568426 ↗02Effectiveness of Herbal Medicines with Anti-Inflammatory, Antimicrobial, and Antioxidant Properties in Improving Oral Health and Treating Gingivitis and Periodontitis: A Systematic ReviewMalcangi G, et al. · Nutrients · 2025PMID 40077632 ↗03Comparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-AnalysisZhang Y, et al. · Nutrients · 2025PMID 40806131 ↗04A systematic review and dose response meta analysis of Omega 3 supplementation on cognitive functionShahinfar H, et al. · Scientific reports · 2025PMID 40836005 ↗Be the first to share what you noticed with Omega-3 (EPA/DHA) for inflammation. How we calculate this.