Compound library
Understand what people are taking.
Browse medicines, supplements, herbs, and health foods. Each profile brings community reports and linked research into one clear view.
Browse medicines, supplements, herbs, and health foods. Each profile brings community reports and linked research into one clear view.
Polyamine found in wheat germ, soybeans and aged cheese, promoted as an autophagy ('cell clean-up') booster because it extends lifespan in animals. In humans even the biochemical step is unconfirmed: placebo-controlled trials at 15 mg and 40 mg a day did not raise blood spermidine, and the largest trial (SmartAge, 12 months, 100 older adults) found no memory benefit.
3 of 6 results reported a benefit, from 4 published studies.
4 randomised trials, 100 people
Side effects: measured in 4 results. No result reported more side effects than the comparison group.
These are the figures the studies reported, not a prediction for any one person. Where several studies measured the same thing in the same unit, we show a simple average and say so. Every individual result is listed below.
See every resultMemory, mental clarity, and overall brain health. Critical for healthy ageing and peak performance.
Also known as: Spermidine (wheat germ extract)
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Spermidine in cognitive function.
Study designs behind these findings.
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Ginkgo biloba for cognitive impairment and dementiaWieland LS, et al. · The Cochrane database of systematic reviews · 2026PMID 41641880 ↗02Effects of acute exercise on cognitive function: A meta-review of 30 systematic reviews with meta-analysesChang YK, et al. · Psychological bulletin · 2025PMID 39883421 ↗03Ginkgo biloba extract EGb 761 is safe and effective in the treatment of mild dementia - a meta-analysis of patient subgroups in randomised controlled trialsRiepe M, et al. · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2025PMID 39895346 ↗04Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysisAmanat S, et al. · Advances in nutrition (Bethesda, Md.) · 2025PMID 40355028 ↗Be the first to share what you noticed with Spermidine for cognitive function. Why counts start empty.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 35616942 2022 | Randomised trial | 100 | 12 months | Mnemonic discrimination performance | -0.03 (95% CI, -0.11 to 0.05; P = .47) | No benefit |
| PMID 33211152 2021 | Randomised trial | 85 | - | MMSE score in mild dementia (higher-dose group) | 2.23 points (p = 0.026) | Benefit |
| PMID 33211152 2021 | Randomised trial | 85 | - | Phonematic fluency in mild dementia (higher-dose group) | 1.99 (p = 0.47) | No benefit |
| PMID 29315079 2018 | Randomised trial | 30 | 3-month | clinical chemistry | reported qualitatively | No benefit |
| PMID 29315079 2018 | Randomised trial | 30 | 3-month | hematological parameters | reported qualitatively | No benefit |
| PMID 29315079 2018 | Randomised trial | 30 | 3-month | self-reported health status | reported qualitatively | No benefit |
| PMID 29315079 2018 | Randomised trial | 30 | 3-month | vital signs | reported qualitatively | No benefit |
| PMID 29315079 2018 | Randomised trial | 30 | 3-month | weight | reported qualitatively | No benefit |
| PMID 30388439 2018 | Randomised trial | 30 | three-months | Memory performance | .17 (95% confidence interval (CI): -.01, .35; 95% CI: 0, 1.53) | Benefit |
| PMID 30388439 2018 | Randomised trial | 30 | three-months | Mnemonic discrimination ability | mean difference = -.11 (95% CI: -.19, -.03; 95% CI: .01, 1.55) | Benefit |