Water-soluble vitamin required for red blood cell formation, myelin synthesis, and DNA production; deficiency, common in older adults and vegans, causes fatigue and neurological symptoms that supplementation corrects.
Chronic tiredness, low energy, and exhaustion not explained by other medical conditions.
Also known as: Methylcobalamin, Cyanocobalamin
Every published result for this pair, extracted and audited.
Research volume over time for Vitamin B12 × fatigue. Structured outcome extraction (direction, effect size) for this pair is in progress - the full analytics will appear here once audited.
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Differences in Ferritin, Vitamin D, and Vitamin B12 Between Fibromyalgia Patients and Healthy Individuals: A Systematic Review and Meta-AnalysisIsmail O, et al. · Musculoskeletal care · 2025PMID 39832803 ↗02Ferric Carboxymaltose (FCM)-Associated Hypophosphatemia (HPP): A Systematic ReviewMagagnoli J, et al. · American journal of hematology · 2025PMID 39935027 ↗03Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systematic ReviewDorczok MC, et al. · Nutrients · 2025PMID 39940333 ↗04Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysisAmanat S, et al. · Advances in nutrition (Bethesda, Md.) · 2025PMID 40355028 ↗Be the first to share what you noticed with Vitamin B12 for fatigue. How we calculate this.