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Water-soluble antioxidant vitamin and essential cofactor for collagen synthesis and non-haem iron absorption; supports immune cell function and skin integrity, and cannot be made by the human body.
Acne, ageing skin, elasticity, hydration, wound healing, and overall skin appearance.
Also known as: Ascorbic Acid
Every published result for this pair, extracted and audited.
These charts group published studies by what they reported and how they were run — green marks studies that reported a benefit for this pairing. Tiers run from pooled analyses of many trials (strongest) to one-off observational reports.
Direction of reported outcomes for Vitamin C in skin health.
Study designs behind these findings.
Every measured outcome, one row per finding - numbers exactly as reported.
| Study | Design | n | Duration | Outcome measured | Reported result | Direction |
|---|---|---|---|---|---|---|
| PMID 15674885 2005 | Meta-analysis | - | - | Photodamage improvement with topical ascorbic acid | reported qualitatively | Benefit |
| PMID 15674885 2005 | Meta-analysis | - | 24 weeks | Photodamage improvement with tretinoin | 1.73 relative risk (95% confidence interval 1.39 to 2.14) | Benefit |
| PMID 15674885 2005 | Meta-analysis | - | 4 to 6 months | Wrinkle score after laser treatment | reported qualitatively | No benefit |
Hand-selected PubMed studies, linked to the originals.
Ordered by strength of evidence, then result direction.
01Efficacy, Durability, and Safety of Collagen Biostimulators Based on Poly-L-Lactic Acid (PLLA) and Calcium Hydroxyapatite (CaHA) in the Face: A Systematic ReviewFerreira ACM, et al. · Aesthetic plastic surgery · 2026PMID 41184662 ↗02Clinical benefits and risks of high-dose intravenous vitamin C: a systematic reviewAlangari A, et al. · Journal of medicine and life · 2026PMID 41815850 ↗03Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026Weiss SL, et al. · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026PMID 41869844 ↗04Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026Weiss SL, et al. · Intensive care medicine · 2026PMID 41870559 ↗Be the first to share what you noticed with Vitamin C for skin health. How we calculate this.